This article is for informational purposes only. As per FDA regulations, we cannot provide medical advice or recommend CBD for any medical use. These statements have not been evaluated by the FDA. Considering we cannot give you advice, we can point you in a direction that has more information.
Relief from chronic pain is by far one of the most common conditions cited by patients for the medical use of cannabis products.1 While many people use CBD oil for pain, more scientific research is needed to be sure it is effective for pain management. Understanding cannabidiol (CBD) and its effects can help overcome the stigma associated with it and enable additional therapeutic uses.
In this article, we will look at what CBD oil is, how CBD oil works, and how people have used it to relieve chronic pain.
What is CBD Oil?
CBD oil is a product that is derived from the cannabis sativa plant species. Most accessible CBD is derived from the industrial hemp strain, which is grown specifically for its industrial uses. Makers of CBD oil use different methods to extract the CBD compound from the industrial hemp plant, and while we will not be going into detail about each extraction method in this article, each form of extracting CBD has its own benefits. The extracted CBD is then added to a carrier oil and called CBD oil. Most common carrier oils for CBD are coconut oil or MCT oil, olive oil, hemp seed oil, sunflower oil, avocado oil and grapeseed oil. CBD oil also comes in many different strengths, with higher concentrations typically being used for more chronic conditions.
How does CBD Oil Work?
The human body has an endocannabinoid system (ECS), a biological system composed of endocannabinoids, whose main function is to maintain bodily homeostasis or biological harmony.2 There are endocannabinoid receptors, which receive and translate signals from cannabinoids, present throughout our body including on our skin, immune cells, bone, fat tissue, liver, pancreas, and skeletal muscle and brain.3 The ECS plays an important role in interacting with a variety of processes including pain, memory, mood, appetite, stress, sleep, metabolism, immune function and reproductive function.4,5 According to a study published in the National Academy of Sciences in 2006, CBD suggests a potential therapeutic role in pain and inflammation by enhancing adenosine receptor signaling and inhibiting adenosine inactivation, essentially activating “off signals” for pain.6
For many people that experience aches and pain, CBD oil has gradually gained recognition as a natural approach to pain relief. The usage of cannabis for pain relief dates to ancient China, where civilizations have transcribed their use of cannabis for a variety of conditions ranging from joint pain, muscle spasms and gout and malaria.7 It is believed that the properties in CBD oil may help with reducing inflammation and ease pain. Based on these studies, research indicates that CBD oil and other CBD products may benefit people with chronic pain.
Medical Research of CBD Oil
In a breakthrough study published in 2017 by the U.S. National Academy of Science, Engineering and Medicine, concluded there may be “substantial evidence” that cannabinoids may be effective for chronic pain, nausea and vomiting during chemotherapy, and spasticity in multiple sclerosis. Cannabinoids have demonstrated the potential for a multitude of therapeutic uses. For example, FDA approved Marinol is a synthetic THC compound used for chemotherapy-induced nausea and vomiting, and appetite and weight loss related to HIV/AIDS.8 Sativex, another drug approved in 30 countries outside of the U.S., is a combination of THC and CBD for muscle spasticity in Multiple Sclerosis.9 Epodiolex, another FDA approved drug, that uses CBD to treat specific pediatric seizure disorders.10
As more patients turn to cannabis for pain relief, there is an urgent need for additional scientific evidence to evaluate the efficacy of cannabinoids and their therapeutic uses. Early evidence suggest that cannabinoids may have potential therapeutic properties including antioxidant, neuroprotective, anti-inflammatory, anti-pain, anti-tumor, anti-psychotic, anti-anxiety and sleep modulation effects. However, it is important to note that these are preliminary hypothesis and current evidence is often limited to animal studies. It will take costly and thorough human clinical trials before we can confirm the efficacy of cannabinoids and determine conditions they could possibly be used for.
What are the benefits of CBD Oil?
The role and benefits of CBD and CBD oil for pain has been the subject of longstanding controversy, especially since there is little scientific research to suggest it’s a safe and effective solution. This has not stopped consumers from finding alternative natural remedies to find relief for their pain. With the spread and ease of access to CBD oil, people have taken it upon themselves to find a method of relief that fits with their lifestyle, whether it’s CBD oil or a CBD balm, CBD Vape, CBD gummies and such.
Part of the growth in using CBD oil for pain has come from personal experiences being posted online and word of mouth; people can find pages upon pages of personal experiences using CBD oil for a variety of aliments on forums such as reddit. The growth in using CBD oil for pain is in stark contrast to comments by the FDA, which ascertains that many of the medical claims of CBD products have been unsubstantiated and that there is not enough evidence to suggest its efficacy.
Does CBD make you high?
Unlike the cannabis intoxicating properties of D9-THC, CBD lacks them and has been traditionally considered non-psychoactive, meaning it does not produce a “high” feeling. According to an article published by The American Society for Experimental NeuroTherapeutics, CBD was found to influence the body to use its own endocannabinoids more effectively, rather than bind to the endocannabinoid receptors much like D9-THC, which is responsible for the high feeling.
How to take CBD Oil?
How CBD is absorbed in your body depends heavily on how you take or consume your CBD oil. Ideally you want your body to absorb most if not all of the CBD you take, meaning larger bioavailability to the cells in your body. The two methods we will be discussing are: (1) Swallowing or ingesting your CBD oil and (2) Taking your CBD oil sublingually or under the tongue. These are by far the most the most common routes of taking CBD oil because of their simplicity.
Orally – Swallowing or ingesting your CBD oil
When CBD is swallowed and ingested, it is absorbed by the digestive system and into the stomach. From the stomach, the compounds are carried into the liver, where the liver metabolizes or breaks down a significant portion of CBD molecules into unusable components and limiting the amount of CBD that is bioavailable to your cells. This is not to say this method of consuming CBD is not effective, but there are better ways of consuming CBD and increasing the amount that is bioavailable to your cells. The best part about taking CBD orally and using this method is that you can take your CBD with your morning coffee or smoothie and at any time of day.
Orally – Taking your CBD oil sublingually or under the tongue
Studies have shown you can use your CBD oil and increase bioavailability if you take it under your tongue and hold it for 30-90 seconds before swallowing. This method of taking CBD oil allows the mucus membranes under your tongue to absorb the compounds. The sublingual method allows CBD to completely bypass the digestive system and the liver metabolism and enter the bloodstream more quickly. Although this method of consuming CBD has better bioavailability for your cells, it does not mean that it makes it a better or a more cost-effective solution. There are other options for consuming CBD that will be covered in another post. The best part about taking your CBD sublingually is its simplicity. You can take your CBD under your tongue first thing in the morning when you get out of bed, in the afternoon on your break or right before bed.
What does CBD oil taste like?
It really depends on the ingredients and carrier oil used in your CBD oil. CBD oil flavors can range from a full-on hemp earthy taste to a more pleasant palatable flavor.
At Avida CBD, we believe we have struck the right balance of flavor with our Avida CBD Oil tinctures. Our CBD oils were crafted from our flagship hemp and carefully formulated to be rich in naturally occurring phytocannabinoids and terpenes. We use only the highest quality ingredients to ensure you get the most therapeutic and natural experience for your well-being. At Avida CBD we create products that are safe, effective, 3rd party lab tested, where quality is guaranteed and taste really good too.
If you have not tried our well-balanced spearmint flavored CBD oils, we invite you to try them risk free for 30 days. If you are not satisfied, simply return it back for a full refund, no questions asked! And believe us, you won’t be disappointed.
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2. Devinsky O, Cross JH, Laux L, et al. Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome. N Engl J Med. 2017;376(21):2011-2020.doi:10.1056/NEJMoa1611618.
3. Mackie K. Cannabinoid receptors: where they are and what they do. J Neuroendocrinol. 2008;20 Suppl 1:10-14. doi:10.1111/j.1365-2826.2008.01671.x.
4. Alger BE. Getting High on the Endocannabinoid System. Cerebrum Dana Forum Brain Sci. 2013;2013.
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8. NIH Drug Database: Dronabinol (Marinol, Synthetic THC). https://druginfo.nlm.nih.gov/drugportal/rn/1972-08- 3.
9. Pharmaceuticlas G. Sativex (delta-9- tetrahydrocannabinol and cannabidiol). https://www.gwpharm.com/products-pipeline/sativex- delta-9-tetrahydrocannabinol-and- cannabidiol.
10. Devinsky O, Cross JH, Laux L, et al. Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome. N Engl J Med. 2017;376(21):2011-2020.doi:10.1056/NEJMoa1611618.